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The best betting sites have San Francisco getting 3.5 points from the visiting Los Angeles Rams. The latter have preyed upon NFC East foes for their four wins. Injuries are still nagging the Niners, who sidelined banged-up quarterback Jimmy Garoppolo last Sunday.

Los Angeles Rams vs. San Francisco 49ers Odds

Team SP/RL TOTAL ML
Rams -3 (-113) 51½ (-115) -170
49ers +3 (-107) 51½ (-105) +148
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Betting LA Rams

The Horned Ones are the road faves per the best online sportsbooks. Los Angeles’ defensive stats are a little swollen as a result of weak NFC East opponents. They have been hurt via the ground, nonetheless.
New York had 136 rushing yards against them in Week 4. Buffalo rushed for 101 yards in Week 3. And Dallas had 136 in Week 1. L.A. ranks 28th in rushing defense DVOA at Football Outsiders, taking into consideration the strength of those opponents.

San Francisco will make the most of that run-heavy attack. That will in turn relieve the pressure on Garoppolo. More importantly, it will give its hobbling defense less time to be exposed.

The Los Angeles Rams are looking for a third win in a row to improve on their 4-1 record. The Los Angeles Rams have split their last eight on the road. Jared Goff is completing 71.7% of his passes for 1,372 yards, eight TDs and three picks. Goff has no touchdown passes in four of his last 13 games.

Cooper Kupp and Robert Woods have a total 663 receiving yards and four TDs. Josh Reynolds has 12 receptions. The Los Angeles Rams are averaging 139.6 rushing yards per game. Darrell Henderson Jr. has 260 yards and three TDs. Los Angeles allows 18 points and 304.2 yards per game. John Johnson has 33 tackles. Aaron Donald has 7.5 sacks. Darious Williams has two interceptions.

Betting San Francisco 49ers

The Niners are the home dogs according to the best betting sites. Head coach Kyle Shanahan told the media he benched Garoppolo from Week 5’s loss to protect him. He was playing on an injured ankle. Jimmy G threw two picks and completed only 7 of 17 passes for 77 yards before getting pulled.

The Niners were losing 30-7 at the half. Rather than risking blowing out Garoppolo’s ankle along with his confidence. Shanahan conceded the loss and started thinking about L.A. A one-legged QB, unless his name is Aaron Rodgers, isn’t the best plan of attack against the Rams vaunted pass defense. San Francisco can counter that with a deep ground attack that’s getting healthier going into Week 6.

The rushing attack still posted 131 yards on just 19 carries against Miami. It could have had more if the 49ers hadn’t been forced to pass after falling into such a deficit. Running back Raheem Mostert returned to the fold this past weekend. He picked up 90 yards on 11 carries. He’s backed by dual-threat Jerick McKinnon. He didn’t do a lot in Week 5, but he can do some damage through the air and on the ground.

The San Francisco 49ers look for a win to get back to .500. The San Francisco 49ers have lost four of their last five at home games. Jimmy Garoppolo is completing 60.6% of his passes for 467 yards, four TDs and two picks. Nick Mullens and Garoppolo have combined for six TD passes and five picks this season.

George Kittle and Kendrick Bourne have a total of 498 receiving yards and two TDs. Brandon Aiyuk has 12 receptions. The San Francisco 49ers averages 129 yards per game. Robert Mostert has 238 yards and one touchdown.

Los Angeles Rams vs. San Francisco 49ers NFL Pick

The Los Angeles Rams.

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