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The best NFL gambling sites opened this game with Green Bay as a five-point favorite. That soon increased to -6 on some of the best online sportsbooks sites with early betting leaning toward the Packers. The 49ers are 5-1 in their past six games, both SU and ATS. The total opened at 47, but it has also gone up. The total has gone OVER in four of the last five encounters between these two teams.

The Green Bay Packers (13-4 SU, 12-5 ATS) hope home-field advantage works in their favor when they receive the San Francisco 49ers (11-7, 10-8) on Saturday in the divisional round. The Packers went undefeated 8-0 this season at Lambeau Field. They outscored opponents by an average of 14 points. Their single loss in their last 15 home games came versus Tampa Bay in last year’s NFC championship game.

49ers vs. Packers NFL Divisional Playoffs Odds by BetOnline

Team SP/RL TOTAL ML
49ers +6 ( -110 ) 47 ( -110 ) +205
Packers -6 ( -110 ) 47 ( -110 ) -255
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Betting San Francisco 49ers

The Niners are road dogs according to the best NFL gambling sites. Starting QB Jimmy Garoppolo was not shy when he was asked about going to Lambeau Field to play the Packers this weekend. He said “we know it’s going to be a tough challenge for us, but we’re ready for it.”

His confidence is at an all-time high after the Niners’ upset win against Dallas in the wild-card round. A win in Green Bay would make those who say Trey Lance will lead the team next year eat crow. Garoppolo has a dual-threat weapon in Deebo Samuel at his disposal.

Samuel led the NFL in yards per catch (18.2). He also averaged 6.2 yards per rush. There are injury concerns, though. Garoppolo sustained a mildly sprained right shoulder versus Dallas. He is expected to play, however.

The news isn’t as good on the other side of the ball. Defensive end Nick Bosa had a concussion. And linebacker Fred Warner injured his ankle last week. They are both in doubt for Saturday’s game.

Betting Green Bay Packers

The Packers are favored by a touchdown at the best NFL gambling sites. The Green Bay Packers head into this game as the favorites to win the Super Bowl (+350). Aaron Rodgers is the odds-on candidate to win MVP (-500).

He has won both of those accolades in the past, but one thing he hasn’t done in his vaunted career is a playoff win over the 49ers. He’s 0-3 against the team for which he grew up rooting. His most recent loss came in the 2019 conference championship game.

Rodgers and the Packers did best San Francisco back in Week 3 with a last-second field goal. Wide receiver Davante Adams posted 132 receiving yards and a TD in that game. Green Bay’s defense held the Niners to 67 yards on the ground. The team will have had plenty of rest coming off a first-round bye. This means that nagging injuries shouldn’t be too much of a problem.

49ers vs. Packers NFL Divisional Playoffs Pick

Let’s try the Packers here. These two met up in Week 3 at Levi’s Stadium. That game was a 30-28 Packers win and a very even affair numbers-wise. San Francisco had a couple of turnovers, and Green Bay managed to score a last-second field goal for the win.

This one’s surely going to be close too, as well as another high-scoring game. Green Bay has scored 30 or more points in six of their past seven games. They’ve also surrendered 28 or more points in five of those games. If San Francisco is able to get their offense going early, we can expect these teams to go toe to toe all the way. Nevertheless, we like Green Bay to get another close win.

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