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The 49ers are up to eight-point favorites in early betting action at the best NFL gambling sites. Meanwhile, the total has dropped to 43.5. The San Francisco 49ers (5-4 SU, 4-5 ATS) will be trying to move into a 1st-place tie on top of the NFC West division in this Week 11 Monday Night Football game as they take on the Arizona Cardinals (4-6, 5-5).

This is a crucial divisional game from Estadio Azteca in Mexico City. The division leaders, the Seahawks, are on bye this week, so the 49ers may be able to pull even with Seattle if they can manage to defeat the Cardinals in the 1st of their 2 meetings this season.

The state of Arizona QB Kyler Murray (hamstring injury) is of course critical to this football game after he missed out last week’s 27-17 upset win against the Los Angeles Rams. The Cardinals went on to cover the point spread in that game as 3.5-point road dogs at the best online sportsbooks. Rams QB Matt Stafford (concussion protocol) also missed the game.

Arizona backup quarterback Colt ‘Cabana’ McCoy improved to a 3-1 record subbing for Murray. That includes last season when Murray missed time as a result of an ankle injury. The drop-off is still big in this spot, though, against a San Francisco defense which is one of the top in the league.

San Francisco 49ers vs. Arizona Cardinals Odds by MyBookie.ag

Team SP/RL TOTAL ML
49ers -8 (-110) 43½ (-110) -370
Cardinals +8 (-110) 43½ (-110) +295
"Bet

Betting San Francisco 49ers

The 49ers showed glimpses of what it is that they can do on offense last Sunday night in a 22-16 win against the Los Angeles Chargers. They goy a few key football players back on the football field after their bye week, which is when they get a week off.

San Francisco failed to cover the point spread as an eight-point home fave at the best NFL gambling sites, but the football team took a chance late and went for a field goal instead after they made it all the way down to the Los Angeles one-yard line.

The Niners welcomed the returning wide receiver Deebo Samuel (who had two catches for 24 receiving yards and four carries for 27 rushing yards) as well as running back Elijah Mitchell (who had 18 carries for 89 rushing yards), who carried the ball more times than the recently signed Christian McCaffrey.

The 49ers continue to try to figure out exactly how to get the ball to all of their offensive weapons in their arsenal, and you can expect that situation to remain unfolding here in prime time.
San Francisco’s defense will eventually determine whether or not the team wins and covers the point spread at the best NFL gambling sites. The 49ers did allow the Chargers to take an early lead last week.

They were fortunate enough to pull off the win late in the football game. If San Francisco is ever going to win and cover the point spread in this one, the defense is going to have to force some turnovers and keep Arizona in check.

Betting Arizona Cardinals

The Cardinals will be hoping that Kyler Murray is going to be back in action with some additional time off in order to heal his injured hamstring. Bettors must keep an eye on his status before kickoff.

Having said that, they are going to be without tight end Zach Ertz. He sustained a potentially season-ending knee injury last week. Ertz had been an important part in Arizona’s passing game with a team-high 47 receptions for 406 receiving yards and four scoring touchdowns. He is going to be missed.

That will add even more pressure on wide receiver DeAndre Hopkins. He would total 10 catches for 98 receiving yards versus the Rams on a team-best 14 targets. Rondale Moore also had 9 catches on 13 targets for 94 receiving yards. That tandem will have to carry the team to victory again.

A quick start will be crucial for Arizona. Murray’s health is the biggest worry. If he is able to run around for the Cards and keep the 49ers busy on defense, then they will have a shot at covering the point spread and perhaps pull off the upset. Hopkins and Moore can and will make plays. They are a more lethal pair than what San Francisco faced last week.

San Francisco 49ers vs. Arizona Cardinals Pick

The 49ers have scored well as of late with 22 points or more in the last three games. Nonetheless, we think Arizona can hang within range and cover.

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