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The Los Angeles Rams travel to San Francisco to take on the 49ers Monday night in a highly- NFC West tilt. It’s a rematch of the conference final last season, The Rams might be coming in as the defending Super Bowl champions, but the hometown Niners are favored by a scant point (total of 42), according to BetUS Sportsbook NFL odds.

Los Angeles Rams vs. San Francisco 49ers Odds by BetUs

Team SP/RL TOTAL ML
Rams +1½ (-110) 42 (-110) +105
49ers -1½ (-110) 42 (-110) -125
Bet Now on this Game

Rams After Third in Row

The Los Angeles Rams are becoming the team many thought they would be to begin the 2022 season. Getting destroyed at home, 31-10, by the Buffalo Bills in the opener seemed to slap them in the face. LA’s two straight wins (home against the Atlanta Falcons and at the Arizona Cardinals) has given it the NFC West lead. LA will understand how important this game is in deciding the division. They are currently sixth choice (+1200) to repeat, as per Super Bowl odds.

The Rams are a middle-of-the-pack passing offense, but struggled running the ball. The backfield of Darrell Henderson Jr and Cam Akers hasn’t worked, as the Rams ranked 30th in rushing yards per game. That doesn’t figure to improve Monday night, as San Francisco’s defense has been awesome.

49ers After Their Revenge

This will mean even more to the San Francisco 49ers and their faithful. The last time these two teams met, visiting San Francisco lost in the NFC title game by a count of 20-17. This season, the 49ers just had a demoralizing-and ugly-11-10 loss at the Denver Broncos last week. It was a game where neither offense could get anything going. San Francisco is 1-2 this season, having lost its opener in soggy Chicago to the Bears, then whipping the Seattle Seahawks at home.

Clearly, the 49ers offense is still attempting to re-integrate quarterback Jimmy Garrapolo, that after an entire offseason of Trey Lance taking the snaps. It was completely out of sync against Denver, totaling only 267 yards (three fumbles and one interception). They cannot afford those miscues against the Rams, who have begun to find their form of last season.

If the 49ers win, it will likely be due to their defense. In any of the first three games, the 49ers’ elite unit has not as much as 20 points, third in the league in points allowed per game (12.3). The 49ers have the NFL’s best pass defense, top-five run defense as well.

LA to Prevail

The 49ers’ stagnant offense fails them once again, with the Rams proving the better side Monday night. When in doubt, there’s the Rams’ connection of quarterback Matthew Stafford and wide receiver Cooper Kupp, presenting a stiff challenge to any defense.

While the Niners’ defense is quite good, they haven’t faced a truly difficult offense, so the numbers are somewhat inflated. LA will be the ones to burst that bubble.

In what’s essentially listed as a pick ‘em, take the visitors.

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