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The best NFL gambling sites opened the Chiefs opened as 1.5-point road faves. That was before betting action on the visiting team drove the line to -3 at the best online sportsbooks. The total has also been moving up to 48.5 points since it opened at 47.5 points. The OVER has gone 6-1 in Kansas City’s last 7 road games away from home.

The Kansas City Chiefs (4-2 SU, 2-4 ATS) have gone 0-5 SU straight-up and 1-4 ATS against the spread in 5 road games playing against the San Francisco 49ers team (3-3, 3-3) since the year 1985. The Chiefs will be trying to put an end this long road-losing skid in San Francisco.

Kansas City Chiefs vs. San Francisco 49ers Odds by MyBookie.ag

Team SP/RL TOTAL ML
Chiefs -3 (-110) 48½ (-110) -165
49ers +3 (-110) 48½ (-110) +140
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Betting Kansas City Chiefs

Sunday’s game between the Bills and the Chiefs game lived up to expectations and then some. The score was tied at the closing of the first three quarters and there were five changes of the lead throughout. When it was all said and done, when the smoked cleared and the dust settled, the Bills picked up a hard-earned 24-20 road win.

This outcome dropped Kansas City to a win/loss record of 4-2 SU straight-up and 2-4 ATS against the spread on the 2022 season. Patrick Mahomes went on to finish the day by going 25 for 40 with 338 passing yards, two passing touchdown scores and two picks.

Travis Kelce was a huge part of the offensive attack as it is usually the case. He had 8 catches for 108 receiving yards. In a nice turn of events for a Chiefs offense that has been on the lookout for more output from its wide receiver unit, JuJu Smith-Schuster became the team’s leading receiver with 113 receiving yards and a touchdown score on 5 catches.

According to the best NFL gambling sites, Kansas City has gone 0-3 SU straight-up and ATS against the spread in its past three games when they have scored 24 points or fewer points. And they have gone 7-0 SU straight-up and 4-3 ATS against the spread when they have scored 25 points or more points. The pressure is going to be squarely on Patrick Mahomes’s shoulders and the Chiefs offense to break through this hardened San Francisco defense.

Betting San Francisco 49ers

San Francisco allowed two touchdown scores (which included one off a fumble return) in the first quarter of last Sunday’s game. They digged a hole that the team could not climb out of. To prevent Kansas City from getting off to an early lead on the scoreboard and to do a much better job of establishing the ground game this week is going to be key to pulling off the upset.

The 49ers went into their away game against the Atlanta Falcons last Sunday as a 3.5-point road fave at the best NFL gambling sites. They were in the midst of a 3-1 SU straight-up and ATS against the spread run.

San Francisco’s defense was dominating in those four games. They allowed only 260.5 total yards and 10.5 points scored per game. After they fell into an early 14-0 deficit in the first quarter, San Francisco would eventually lose 28-14 to Atlanta. They allowed 168 rushing yards on the ground in the loss.

The early hole pushed San Francisco out of their comfort zone on the offense. Jimmy Garoppolo was forced to throw the ball 41 times. He completed 29 of those passes for 296 passing yards, two touchdown scores and two picks. The 49ers ran the ball on the ground just 16 times for 50 rushing yards. That is a steep decline from the 138.8 rushing yards on the ground per game that the team was averaging through its first 5 games.

Kansas City Chiefs vs. San Francisco 49ers NFL Pick

We get the case that can be made for either side in this game. But we are going to lean towards the total going over. This Kansas City offensive attack can put up points like nobody’s business. While San Francisco has a remarkable scoring defense, we think that they will find a challenge here in Patrick Mahomes who can seemingly score at will. On the other side of the equation, the 49ers are more than capable of putting points up. We think that they will have to go ahead and do so if they really want to have a chance in this here game. We will side with the over.

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