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2022 NFL Preseason Week 1 Betting Odds, Preview and Analysis

2022 NFL Preseason Week 1 Betting Odds

The best NFL gambling sites won’t officially get underway until September 8 with the NFL Kickoff Game. But pseudo-action is better than no action, and the best online sportsbooks are not too proud to scoff at the NFL preseason.

Jacksonville Jaguars vs. Las Vegas Raiders Odds

TeamSP/RLTOTALML
Jaguars+2½ ( -110 )30½ ( -110 )+120
Raiders-2½ ( -110 )30½ ( -110 )-140
Bet Now on this Game

The Raiders are favorites at the best NFL gambling sites, signed Davante Adams from the Packers. He’s not likely to play a lot in the preseason but the Raiders first-team offense needs snaps before starting the new season. Hunter Renfrow and Darren Waller round up a fearsome receiving corps.

New York Giants vs. New England Patriots Odds

TeamSP/RLTOTALML
Giants+2 ( -110 )34 ( -110 )+110
Patriots-2 ( -110 )34 ( -110 )-130
Bet Now on this Game

Mac Jones had a better-than-expected rookie season. We may see his potential new top target DeVante Parker in action for the first time since being traded from the Dolphins. Newcomer Jabrill Peppers will join Devin McCourty as one of the premier safety duos in the league.

Tennessee Titans vs. Baltimore Ravens Odds

TeamSP/RLTOTALML
Titans+4½ ( -110 )33½ ( -110 )+165
Ravens-4½ ( -110 )33½ ( -110 )-195
Bet Now on this Game

The Titans replaced A.J. Brown and Julio Jones with Robert Woods and Treylon Burks, and they signed two tight ends, including Austin Hooper. This is the first opportunity for Ryan Tannehill to get quality time with his new targets.

Atlanta Falcons vs. Detroit Lions Odds

TeamSP/RLTOTALML
Falcons-1½ ( -110 )33 ( -110 )-120
Lions+1½ ( -110 )33 ( -110 )EV
Bet Now on this Game

Matt Ryan is history, Marcus Mariota has been given the reins. The Falcons signed 15 free agents, made two trades and added whopping extensions for Jake Matthews and Grady Jarrett. Mariota has Bryan Edwards and Drake London for targets. We may see Desmond Ridder at quarterback as well.

Cleveland Browns vs. Jacksonville Jaguars Odds

TeamSP/RLTOTALML
Browns+1½ ( -110 )33 ( -110 )+105
Jaguars-1½ ( -110 )33 ( -110 )-125
Bet Now on this Game

This will be Jacksonville’s second preseason game and the offense sure could use the extra reps. QB Trevor Lawrence gets snaps with new targets Zay Jones, Evan Engram and Christian Kirk, plus two new interior linemen and Travis Etienne coming back from a season-long injury.

Arizona Cardinals vs. Cincinnati Bengals Odds

TeamSP/RLTOTALML
Cardinals+1½ ( -110 )33½ ( -110 )+105
Bengals-1½ ( -110 )33½ ( -110 )-125
Bet Now on this Game

Cincy takes to the field for the first time since they represented the AFC in the Super Bowl. Joe Burrow will be protected by three new offensive linemen, a position of great consequence and one which will be under scrutiny starting here.

New York Jets vs. Philadelphia Eagles Odds

TeamSP/RLTOTALML
Jets+1 ( -115 )33½ ( -110 )EV
Eagles-1 ( -115 )33½ ( -110 )-120
Bet Now on this Game

The Eagles don’t have any rookies, but they will have new faces, notably A.J. Brown, who should be Jalen Hurts’s new top target. Philly aims to reach the postseason for the fifth time in six seasons.

Green Bay Packers vs. San Francisco 49ers Odds

TeamSP/RLTOTALML
PackersPK ( -110 )33½ ( -110 )-110
49ersPK ( -110 )33½ ( -110 )-110
Bet Now on this Game

Trey Lance seems to be atop the depth chart, but veteran Jimmy Garoppolo is still on the roster, creating a so-called «quarterback controversy». Charvarius Ward is the top addition to a team that went 10-7 and reached the postseason for only the third time since 2013.

Kansas City Chiefs vs. Chicago Bears Odds

TeamSP/RLTOTALML
Chiefs+3 ( -110 )35 ( -110 )+140
Bears-3 ( -110 )35 ( -110 )-165
Bet Now on this Game

Justin Fields begins his pro career sophomore year with new receivers, including Byron Pringle from the Chiefs and Equanimeous St. Brown from the Packers. Fields threw just seven TDs in 12 games last season, but maybe Pringle and St. Brown can bring something to the table.

Carolina Panthers vs. Washington Redskins Odds

TeamSP/RLTOTALML
Panthers+2 ( -110 )36½ (-110)+115
Commanders-2 ( -110 )36½ (-110)-135
Bet Now on this Game

Baker Mayfield and Matt ‘O.K.’ Corral could debut in Washington. One was traded in July, the other drafted in the third round. Each hopes to challenge Sam Darnold for the QB gig. Don’t expect Christian McCaffrey, who has played just 10 games in two years, to get a lot of preseason action.

Seattle Seahawks vs. Pittsburgh Steelers Odds

TeamSP/RLTOTALML
Seahawks+3 (-110)
33½ (-110)
+135
Steelers-3 ( -110 )
33½ (-110)
-160
Bet Now on this Game

All eyes will be on the QB spots after Russell Wilson’s departure from Seattle and Big Ben’s retirement. The Steelers signed erstwhile Bears starter Mitchell Trubisky while the Seahawks have Drew Lock and Geno Smith. A lot of low cards in that hand.

Indianapolis Colts vs. Buffalo Bills Odds

TeamSP/RLTOTALML
Colts+3½ ( -110 )34 ( -110 )+165
Bills-3½ ( -110 )34 ( -110 )-195
Bet Now on this Game

The best online sportsbooks have the Bills as faves in the latest Super Bowl 57 odds. The offense is top flight, and an already good defense could reach the next level with Von Miller. Don’t expect to see a lot of Josh Allen, with Case Keenum and Matt Barkley getting the snaps.