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The best College Football betting sites have a great lineup of Week 4 college football matchups between teams that are ranked in the AP Top 25 Poll. The game pitting No. 6 Ohio State versus No. 9 Notre Dame is the attraction of the week. It will be sharing the prime-time slot with No. 25 Iowa versus No. 7 Penn State in a so-called whiteout game.

Florida State Seminoles vs. Clemson Tigers Odds By BetOnline

Team SP/RL TOTAL ML
Florida State -1½ ( -110 ) 55 ( -110 ) -125
Clemson +1½ ( -110 ) 55 ( -110 ) +105
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Jordan Travis led Florida State to a comeback in the fourth quarter in last season’s 34-28 loss last year. This is going to be an opportunity to snape the Tigers’ seven-game winning streak in the series between the two teams.

Clemson has kept opposing QBs to a 52.1 percent completion percentage. Travis is going to have to do his best with his targets. On the other hand, Cade Klubnik has a 38.2 percent completion percentage when he is under pressure.

Will the Tigers be able to keep him intact versus the Seminoles’ pass rush? This just might be one of those trademarked Clemson upsets, including the obligatory emotional Dabo Swinney speech following the game.

Florida State vs. Clemson Pick: Clemson upsets Florida State 31-24

Ole Miss Rebels vs. Alabama Crimson Tide

Team SP/RL TOTAL ML
Ole Miss +7 ( -110 ) 55 ( -110 ) +230
Alabama -7 ( -110 ) 55 ( -110 ) -280
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Is it too early to fade Alabama? Nick Saban has not been able to find the right QB, and it became apparent in a 17-3 win over South Florida. We are tempted to back Ole Miss here. Lane Kiffin has the offense firing on all cylinders, while Jaxson Dart boasts a 202.5 efficiency rating.

Just six other FBS QBs can say the same. Then, why do we hesitate to pick the Crimson Tide to drop two straight games in a row at Bryant-Denny Stadium for the first time since the 2007 season? Jalen Milroe will be getting the start, and the Crimson Tide will win an ugly victory.

Ole Miss vs. Alabama Pick: Alabama wins 28-24 but does not cover the spread at the best online sportsbooks.

UCLA vs. Utah Odds

Team SP/RL TOTAL ML
UCLA +4½ ( -110 ) 51 ( -110 ) +170
Utah -4½ ( -110 ) 51 ( -110 ) -200
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UCLA defeated Utah 42-32 last year, but now the Bruins are going to have to go on the road. Freshman Dante Moore has been enjoying a quick start at QB, and UCLA has a high-caliber ground game.

The Bruins went on to score 28 points in the second half. They averaged 5.3 yards per carry versus the Utes last year. It is going to be a different ball game away from home. Utah has gone 23-1 SU and 15-9 ATS against the point spread at home since the 2019 season. Nate Johnson is a remarkable freshman QB.

UCLA vs. Utah Pick: Utah is going to win 34-27 and will cover the point spread.

Colorado vs. Oregon College Football Odds

Team SP/RL TOTAL ML
Colorado +21 ( -110 ) 71 ( -110 ) +675
Oregon -21 ( -110 ) 71 ( -110 ) -950
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The best betting sites have set this point spread high, maybe because Colorado is going to be without Travis Hunter. He was taken out of Week 3’s game versus Colorado State as a result of a late hit.
Oregon’s offensive attack is going to be the best challenge up to this point for Colorado’s defense, which has been allowing 5.0 yards per carry. The Ducks have gone 7-1 SU and 7-1 ATS against the spread at home with second-year head coach Dan Lanning.

The single loss took place against Washington last year. The Buffaloes will be taking their first loss with head coach Deion Sanders, but Shedeur Sanders will make enough plays through the air to steal the cover.

Colorado vs. Oregon Pick: Oregon is going to win the game 48-28 but will not cover the point spread.

Oregon State vs. Washington State Odds

Team SP/RL TOTAL ML
Oregon State -3 ( -110 ) 56 ( -110 ) -145
Washington State +3 ( -110 ) 56 ( -110 ) +125
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The Beavers went on to win the so-called Left Behind Bowl 24-10 last year. That would break Washington State’s eight-game winning streak in this matchup. Oregon State has not been able to win at Martin Stadium since the 2013 season.

This is going to be a fun display for QB play with Oregon State’s D.J. Uiagalelei and Washington State’s Cameron Ward. Wards is going to lead a late scoring drive for the go-ahead TD, and the Cougars will be coming up with a second outstanding September win at home.

Oregon State vs. Washington State Pick: Washington State is going to upset 31-25

Ohio State vs. Notre Dame Odds

Team SP/RL TOTAL ML
Ohio State -3 ( -110 ) 55½ ( -110 ) -160
Notre Dame +3 ( -110 ) 55½ ( -110 ) +135
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We thought that this line would be higher at the best betting sites considering the way that Ohio State’s offensive attack looked in Week 3 with Kyle McCord finding his niche as the starting QB. The Buckeyes have gone on to win the last six encounters (including two bowl games) by an average winning margin of 14.6 points per game.

Sam Hartman has shifted the conversation a little, and Notre Dame features a big-play attack through the air. Will they be able to make enough plays versus an enhanced Buckeyes’ defense that gives up just 6.7 points per game? Should this line tick up during the week, then we are going to be even more confident.

Ohio State vs. Notre Dame Pick: Ohio State is going to win the game 31-24 and will cover the point spread.

Iowa vs. Penn State College Football Odds

Team SP/RL TOTAL ML
Iowa +14½ ( -110 ) 40 ( -110 ) +465
Penn State -14½ ( -110 ) 40 ( -110 ) -630
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Penn State dropped the last two games with Iowa, but this squad has a better look now. The Nittany Lions have zero turnovers in three weeks with starting QB Drew Allar. The defense has been limiting opponents to 3.1 yards per rush.

This might be similar to last week’s game against Illinois. The Hawkeyes have gotten better on offense, and Cade McNamara won at Beaver Stadium in his last start in the 2021 season, though with Michigan. The Whiteout is going to make a difference. Penn State will roll on.

Iowa vs. Penn State Pick: Penn State is going to win the game 35-16 and will cover the point spread.

UAB vs. Georgia College Football Odds

Team SP/RL TOTAL ML
UAB +42 ( -110 ) 54 ( -110 )   –
Georgia -42 ( -110 ) 54 ( -110 )   –
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UAB vs. Georgia Pick: Georgia is going to win the game 49-10 but will not cover the point spread.

Texas vs. Baylor Odds

Team SP/RL TOTAL ML
Texas -15 ( -110 ) 51½ ( -110 ) -650
Baylor +15 ( -110 ) 51½ ( -110 ) +475
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Texas vs. Baylor Pick: Texas is going to win the game 38-28 but will not cover the point spread.

North Carolina vs. Pittsburgh U Odds

Team SP/RL TOTAL ML
North Carolina -7½ ( -110 ) 50 ( -110 ) -300
Pittsburgh U +7½ ( -110 ) 50 ( -110 ) +240
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North Carolina vs. Pittsburgh Pick: North Carolina wins 30-22 and covers the spread.

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