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Buffalo Bills vs. New Orleans Saints Best Bets for Thanksgiving 2021 Game

Buffalo Bills best betting odds and predictions
  • by Anthony Carpenter
  • November 24th, 2021
  • Category:

The best USA sportsbooks favor the Bills over the Saints when they play on Thursday in week 12 of NFL action at Caesars Superdome. The Buffalo Bills are looking for a win after going 3-3 in their last six games. The New Orleans Saints look to end a three-game losing skid.

If the season were to ended today, Buffalo and New Orlean would be seeded 7th in their respective conferences. The Bills are 2-3 SU and 1-3-1 ATS in their last five games, according to the best online sportsbooks. The Saints have lost three in a row. New Orleans opened as a three-point home underdog at the best USA sportsbooks.

Gamblers still believe in the Bills. Thy bet Buffalo up to a 4.5-point fave by Monday. The UNDER was an equally popular choice in early action. The total dropped as low as 46 at many of the best USA sportsbooks.

Buffalo Bills vs.  New Orleans Saints NFL Odds by MyBookie.ag

Bills-6 ( -110 )45 ( -110 )-255
Saints+6 ( -110 )45 ( -110 )+205
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Betting Buffalo Bills

After Sunday’s 41-15 home loss to Indianapolis, the Bills face questions as to whether they can legitimately contend for the AFC title. Buffalo is 5-1 SU and 4-1-1 ATS against teams under .500. And 1-3 SU and ATS against opponents with winning records.

Indy owned the Bills on the ground. They ran for five touchdowns and finished with 264 rushing yards. Buffalo shot themselves in the foot. They turned the ball over four times. They failed to create a takeaway.

“What we put on that field today is not who we are,” Josh Allen said. Lucky for the Bills, they are great at bouncing back from ugly losses under coach Sean McDermott. Buffalo is 3-0-1 ATS in their last four games after a SU loss. As well as 9-1-1 ATS in their last 11 after a SU loss of 14 points or higher. The Bills have covered seven in a row against the NFC. They are 5-1 SU and ATS in their last six prime-time games.

Betting New Orleans Saints

The Saints have struggled valiantly since they lost starting QB Jameis Winston to injury. Having little margin for error could be taking its toll, though. Following consecutive two-point losses to Atlanta and Tennessee, New Orleans was obliterated from the field last week in Philadelphia.

They trailed 27-7 at halftime and 33-7 through three quarters prior to a late rally that made the final score 40-29. The early deficit forced the Holy Ones to go to the air more than they would have liked to with backup quarterback Trevor Siemian.

He was under pressure all day long. He threw his first two picks of the season. Siemian was without Alvin Kamara. He missed his second game in a row with a knee injury. Kamara could be out again after the team said on Monday that he wouldn’t have practiced if it were a regular week. Should Kamara not be able to suit up, expect another busy night for Mark Ingram. He had 88 yards on 16 carries against Philadelphia.

Buffalo Bills vs. New Orleans Saints NFL Pick

The Buffalo Bills should be able to win this game by a good enough margin. Still, they shouldn’t have gotten the prison beating the Colts gave them or lost to the Jags. The New Orleans Saints have their problems as well, and who would have thunk it that Siemian would be a step back from Jameis Winston? Having said that, we’re getting a free TD with the home team on a short week. We also have lost much confidence in the Bills. Take the New Orleans Saints.