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Bills vs. 49ers NFL Betting Lines, Predictions and Picks for MNF Week 13

San Francisco 49ers NFL Betting Season odds, expert picks and analysis

The best offshore sportsbooks for US players had the visiting Bills as 2.5-point favorites. However, early action has lowered the spread to just one point, with the total at 47.

Buffalo Bills vs. San Francisco 49ers NFL Odds By GTBets.eu

TeamSP/RLTOTALML
Bills+1 (-110)47½ (-105)-105
49ers-1 (-110)47½ (-115)-115
Bet Now on this Game

Betting Buffalo Bills

According to the best online sportsbooks, the Bills are 0-3-1 ATS in their last four Monday Night appearances. No one would blame the Bills for getting PTSD when returning to State Farm Stadium. Three weeks ago, they sustained a last-second loss to the Cardinals on what’s some call the “Hail Murray” play.

Buffalo could still be traumatized from that game. The Bills had a bye week to lick their wounds but returned to action last week hosting the Chargers. And delivering an underwhelming performance in a 27-17 win. Buffalo had three TOs in the second half. QB Josh Allen had just 157 passing yards (and two TOs of his own), against the 23rd-ranked DVOA defense.

Buffalo needs to shake the cobwebs off against a 49ers team coming off a 23-20 OT win over the Rams. That left them just one game out of a playoff berth in the NFC. Starting QB Jimmy Garoppolo and star tight end George Kittle remain sidelined, but the offense has top receiver Deebo Samuel and running back Raheem Mostert.

And the defense is still showing up. The Niners held the Rams to 308 total yards and forced four TOs in their Week 12 win. They will look to cause more damage for Allen, who has had several turnovers in each of his past two games.

Betting San Francisco 49ers

San Francisco is 13-3 ATS in their last 16 Monday games, per the best offshore sportsbooks for US players. The Niners desperately needs a win. The 49ers are also 1-4 SU and ATS at home this season. Of course, this will be a home game only nominally. Thus, we can set more stock in their 4-2 SU/ATS record on the road.

Buffalo Bills vs. San Francisco 49ers Pick

The Buffalo Bills keep finding themselves in tight games. One is almost waiting for the wheels to come off, but they keep winning and getting things done in the games that matter. The San Francisco 49ers had arguably their best game last week. A road win over the Rams, and the defense is coming through big time.

A defense that is only going to get better with the return of Richard Sherman. Having said all that, the Bills are almost being underestimated with this line. They have been the superior and more consistent team this year. One would need more points to even consider backing the 49ers in this game.

As for the total, last week’s game ended a three-game Over streak for Buffalo. San Francisco has seen the Under pay off in two consecutive games and four of their last six. With the total at 47, we’re thinking it will go Under for Monday’s game. San Francisco has Mostert back. He struggled against the Rams last week. But he should be ready to make the most of Buffalo’s 22nd-ranked DVOA rush defense. That should help run the clock and decrease Buffalo’s chances to score.

On the other hand, the Bills also displayed an unsuspected dedication to running the ball last week. They torched the Chargers for 172 yards on the ground. With a Niners defense that ranks fourth in QB hurry percentage, Buffalo will again use the run to take the pressure off of Allen and limit his chances to make turnovers. A lot of running, and a Niners defense that has surrendered just one 300-yard passing game all season, should have users of the best offshore sportsbooks for US players backing the Under.