2021 NFL Week 1 Full Odds, Analysis and Expert Picks
NFL gambling sites have their favorites and underdogs for week 1 of the 2021 NFL season. All odds are from My Bookie, one of the best online sportsbooks.
Cowboys vs. Buccaneers Odds by MyBookie.ag
|Dallas Cowboys||+7½ ( -110 )||51½ ( -110 )||+290|
|Buccaneers||-7½ ( -110 )||51½ ( -110 )||-360|
The Bucs retained every key player of their championship who could have gone elsewhere. Tom Brady was clicking in Bruce Arians’ system by the end of the season and should be in full command of the playbook by now.
Steelers vs. Bills Odds by MyBookie.ag
|Pittsburgh Steelers||+6½ ( -110 )||48½ ( -110 )||+235|
|Buffalo Bills||-6½ ( -110 )||48½ ( -110 )||-290|
The Bills were 9-1 SU in Orchard Park in 2020. That includes the playoffs. They boasted an average winning margin of 8.5 points.
Jets vs. Panthers Odds by MyBookie.ag
|New York Jets||+5 ( -110 )||44½ ( -110 )||+195|
|Carolina Panthers||-5 ( -110 )||44½ ( -110 )||-245|
The Jets will start out a rookie QB. Meanwhile, Sam Darnold goes against his old teammates. Carolina went just 2-6 at home SU and ATS in 2020.
Jaguars vs. Texans Odds by MyBookie.ag
|Jacksonville Jaguars||-2½ ( -125 )||44½ ( -110 )||-150|
|Houston Texans||+2½ ( +105 )||44½ ( -110 )||+130|
Both teams’ defenses were among the NFL’s worst last season. There’s quite a bit of uncertainty about Deshaun Watson’s situation. The narrow number favoring Jacksonville at NFL gambling sites isn’t too surprising.
Cardinals vs. Titans Odds by MyBookie.ag
|Arizona Cardinals||+3 ( -115 )||52 ( -110 )||+135|
|Tennessee Titans||-3 ( -105 )||52 ( -110 )||-160|
Tennessee added Julio Jones to their already lethal offense that includes Ryan Tannehill and Derrick Henry.
Chargers vs. Washington Odds by MyBookie.ag
|Los Angeles Chargers||-1 ( -110 )||44½ ( -110 )||-120|
|Washington||+1 ( -110 )||44½ ( -110 )||EV|
Ryan Fitzpatrick is the new starter under center for the Skins. Curtis Samuel and Adam Humphries are part of a receiving unit overhaul.
Eagles vs. Falcons Odds by MyBookie.ag
|Philadelphia Eagles||+3½ ( -115 )||48 ( -110 )||+155|
|Atlanta Falcons||-3½ ( -105 )||48 ( -110 )||-185|
A new head coach, the offensive-minded Arthur Smith, should be a much-needed shot in the arm for Matt Ryan and Co.
Vikings vs. Bengals Odds by MyBookie.ag
|Minnesota Vikings||-3 ( -115 )||48 ( -110 )||-170|
|Cincinnati Bengals||+3 ( -105 )||48 ( -110 )||+145|
Joe Burrow and Joe Mixon are reportedly fully healthy, and the former will reunite with LSU receiver Ja’Marr Chase.
49ers vs. Lions Odds by MyBookie.ag
|San Francisco 49ers||-7½ ( -105 )||45½ ( -110 )||-350|
|Detroit Lions||+7½ ( -115 )||45½ ( -110 )||+280|
Jimmy Garoppolo is competing with No. 3 overall pick Trey Lance. But whoever gets the starting gig will have the target threesome of Deebo Samuel, Brandon Aiyuk and George Kittle.
Browns vs. Chiefs Odds by MyBookie.ag
|Cleveland Browns||+6 ( -110 )||53 ( -110 )||+225|
|Kansas City Chiefs||-6 ( -110 )||53 ( -110 )||-275|
The opening spread at NFL gambling sites appears to be a sign of respect for Coach Stefanski’s squad. It’s worth noting the Chiefs lost two games SU at Arrowhead last season.
Dolphins vs. Patriots Odds by MyBookie.ag
|Miami Dolphins||+2½ ( -105 )||44 ( -110 )||+130|
|New England Patriots||-2½ ( -115 )||44 ( -110 )||-150|
The Pats will rely on rookie QB Mac Jones in this game. The Alabama product won the starting position over Cam Newton in the preseason.
Broncos vs. Giants Odds by MyBookie.ag
|Denver Broncos||-2½ ( -115 )||42½ ( -110 )||-150|
|New York Giants||+2½ ( -105 )||42½ ( -110 )||+130|
The Broncos open as road faves despite their 5-11 record from a year ago. Denver was notably 5-3 ATS on the road last season.
Packers vs. Saints Odds by MyBookie.ag
|Green Bay Packers||-4½ ( -110 )||50 ( -110 )||-210|
|New Orleans Saints||+4½ ( -110 )||50 ( -110 )||+175|
The Saints are setting themselves up to fail with loser QB Jameis Winston under center.
Bears vs. Rams Odds by MyBookie.ag
|Chicago Bears||+7½ ( -115 )||44½ ( -110 )||+280|
|Los Angeles Rams||-7½ ( -105 )||44½ ( -110 )||-350|
Stafford should be an upgrade. The only question is how in-synch he’ll be with Robert Woods, Cooper Kupp and DeSean Jackson, and tight end Tyler Higbee.