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2021 NFL Week 1 Full Odds, Analysis and Expert Picks

NFL Week 1: Ultimate betting guide to every game with betting sites odds

NFL gambling sites have their favorites and underdogs for week 1 of the 2021 NFL season. All odds are from My Bookie, one of the best online sportsbooks.

Cowboys vs. Buccaneers Odds by MyBookie.ag

TeamSP/RLTOTALML
Dallas Cowboys+7½ ( -110 )51½ ( -110 )+290
Buccaneers -7½ ( -110 )51½ ( -110 )-360
Bet Now on this Game

The Bucs retained every key player of their championship who could have gone elsewhere. Tom Brady was clicking in Bruce Arians’ system by the end of the season and should be in full command of the playbook by now.

Pick: Bucs.

Steelers vs. Bills Odds by MyBookie.ag

TeamSP/RLTOTALML
Pittsburgh Steelers +6½ ( -110 )48½ ( -110 )+235
Buffalo Bills -6½ ( -110 )48½ ( -110 )-290
Bet Now on this Game

The Bills were 9-1 SU in Orchard Park in 2020. That includes the playoffs. They boasted an average winning margin of 8.5 points.

Pick: Bills.

Jets vs. Panthers Odds by MyBookie.ag

TeamSP/RLTOTALML
New York Jets+5 ( -110 )44½ ( -110 )+195
Carolina Panthers -5 ( -110 )44½ ( -110 )-245
Bet Now on this Game

The Jets will start out a rookie QB. Meanwhile, Sam Darnold goes against his old teammates. Carolina went just 2-6 at home SU and ATS in 2020.

Pick: Panthers.

Jaguars vs. Texans Odds by MyBookie.ag

TeamSP/RLTOTALML
Jacksonville Jaguars -2½ ( -125 )44½ ( -110 )-150
Houston Texans +2½ ( +105 )44½ ( -110 )+130
Bet Now on this Game

Both teams’ defenses were among the NFL’s worst last season. There’s quite a bit of uncertainty about Deshaun Watson’s situation. The narrow number favoring Jacksonville at NFL gambling sites isn’t too surprising.

Pick: Texans.

Cardinals vs. Titans Odds by MyBookie.ag

TeamSP/RLTOTALML
Arizona Cardinals +3 ( -115 )52 ( -110 )+135
Tennessee Titans -3 ( -105 )52 ( -110 )-160
Bet Now on this Game

Tennessee added Julio Jones to their already lethal offense that includes Ryan Tannehill and Derrick Henry.

Pick: Titans.

Chargers vs. Washington Odds by MyBookie.ag

TeamSP/RLTOTALML
Los Angeles Chargers-1 ( -110 )44½ ( -110 )-120
Washington+1 ( -110 )44½ ( -110 )EV
Bet Now on this Game

Ryan Fitzpatrick is the new starter under center for the Skins. Curtis Samuel and Adam Humphries are part of a receiving unit overhaul.

Pick: Washington.

Eagles vs. Falcons Odds by MyBookie.ag

TeamSP/RLTOTALML
Philadelphia Eagles+3½ ( -115 )48 ( -110 )+155
Atlanta Falcons-3½ ( -105 )48 ( -110 )-185
Bet Now on this Game

A new head coach, the offensive-minded Arthur Smith, should be a much-needed shot in the arm for Matt Ryan and Co.

Pick: Falcons.

Vikings vs. Bengals Odds by MyBookie.ag

TeamSP/RLTOTALML
Minnesota Vikings-3 ( -115 )48 ( -110 )-170
Cincinnati Bengals+3 ( -105 )48 ( -110 )+145
Bet Now on this Game

Joe Burrow and Joe Mixon are reportedly fully healthy, and the former will reunite with LSU receiver Ja’Marr Chase.

Pick: Bengals.

49ers vs. Lions Odds by MyBookie.ag

TeamSP/RLTOTALML
San Francisco 49ers-7½ ( -105 )45½ ( -110 )-350
Detroit Lions+7½ ( -115 )45½ ( -110 )+280
Bet Now on this Game

Jimmy Garoppolo is competing with No. 3 overall pick Trey Lance. But whoever gets the starting gig will have the target threesome of Deebo Samuel, Brandon Aiyuk and George Kittle.

Pick: 49ers.

Browns vs. Chiefs Odds by MyBookie.ag

TeamSP/RLTOTALML
Cleveland Browns+6 ( -110 )53 ( -110 )+225
Kansas City Chiefs-6 ( -110 )53 ( -110 )-275
Bet Now on this Game

The opening spread at NFL gambling sites appears to be a sign of respect for Coach Stefanski’s squad. It’s worth noting the Chiefs lost two games SU at Arrowhead last season.

Pick: Chiefs.

Dolphins vs. Patriots Odds by MyBookie.ag

TeamSP/RLTOTALML
Miami Dolphins+2½ ( -105 )44 ( -110 )+130
New England Patriots-2½ ( -115 )44 ( -110 )-150
Bet Now on this Game

The Pats will rely on rookie QB Mac Jones in this game. The Alabama product won the starting position over Cam Newton in the preseason.

Pick: Patriots.

Broncos vs. Giants Odds by MyBookie.ag

TeamSP/RLTOTALML
Denver Broncos-2½ ( -115 )42½ ( -110 )-150
New York Giants+2½ ( -105 )42½ ( -110 )+130
Bet Now on this Game

The Broncos open as road faves despite their 5-11 record from a year ago. Denver was notably 5-3 ATS on the road last season.

Pick: Broncos.

Packers vs. Saints Odds by MyBookie.ag

TeamSP/RLTOTALML
Green Bay Packers-4½ ( -110 )50 ( -110 )-210
New Orleans Saints+4½ ( -110 )50 ( -110 )+175
Bet Now on this Game

The Saints are setting themselves up to fail with loser QB Jameis Winston under center.

Pick: Packers.

Bears vs. Rams Odds by MyBookie.ag

TeamSP/RLTOTALML
Chicago Bears+7½ ( -115 )44½ ( -110 )+280
Los Angeles Rams-7½ ( -105 )44½ ( -110 )-350
Bet Now on this Game

Stafford should be an upgrade. The only question is how in-synch he’ll be with Robert Woods, Cooper Kupp and DeSean Jackson, and tight end Tyler Higbee.

Pick: Rams.