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2021 MLB Opening Day Betting Team by Team Odds, Picks and Predictions

2021 MLB Opening Day Game Odds, Picks and Predictions

The Opening Day of the 2021 MLB season is upon us. That means you don’t have to wait to wager at the best betting sites on the slew of action we’re going to witness on April 1. Unlike past seasons, when MLB had a couple of highlight games the day prior to Opening Day proper, all 30 teams are slated to open their season on Thursday, April 1. The action begins as early as 1:05 p.m. ET and as late as 10:10 p.m. ET.

Toronto Blue Jays vs. New York Yankees, 1:05 p.m. ET

TeamOdds
Blue Jays+135
Yankees-165


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The Blue Jays reached the expanded postseason in 2020. They look to keep moving forward in 2021. They added George Springer and Marcus Semien, as well as others. Also they will open against the powerhouse Yankees, who had an uneventful offseason after they finished second to the Rays in the division last year. The awaited starting pitching matchup would put Hyun-Jin Ryu against Gerrit Cole.

Cleveland Indians vs. Detroit Tigers, 1:10 p.m. ET

TeamOdds
Indians-175
Tigers+140


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Even though they traded Francisco Lindor in the offseason, Cleveland opens as a solid favorite. They have 63.6% implied odds. They go against the overhauling Tigers. That percentage is probably due to having current Cy Young winner Shane Bieber on the pitching mound. With an abundance of young talent but with no clear sense of who will start, the Tigers could give the nod to the once No. 1-overall pick Casey Mize. Or they could go with a dependable veteran like Matthew Boyd or José Ureña.

Baltimore Orioles vs. Boston Red Sox, 2:10 p.m. ET

TeamOdds
Orioles+160
Red Sox-200


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The Orioles are again expected to continue their backward momentum. No one sees the Red Sox aren’t competing for a playoff berth, but they certainly have a better roster. The pitching matchup here is not clear. Barring any unforeseen event good, it will likely feature John Means against Eduardo Rodríguez.

Minnesota Twins vs. Milwaukee Brewers, 2:10 p.m. ET

TeamOdds
Twins-150
Brewers+120


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An interleague clash between two 2020 playoff teams is very alluring. The Twins are looking to surpass the White Sox in the American League Central race. The Brewers expect to go toe to toe with St. Louis atop the National League Central. Minnesota will be starting Kenta Maeda in lieu of José Berríos. The Brewers’ best bet is Brandon Woodruff.

Pittsburgh Pirates vs. Chicago Cubs, 2:20 p.m. ET

TeamOdds
Pirates+180
Cubs-225


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The Cubs are one of the biggest Opening Day faves. This is mostly because of their competition, or lack thereof. The Pirates boast the lowest win total in baseball. They will be surrounding their only star, Ke’Bryan Hayes, with a who’s who of non-entities. The best choice to start on Opening Day for Pittsburgh is Mitch Keller. The Cubs traded Yu Darvish during the offseason, so they will likely resort to Kyle Hendricks.

Atlanta Braves vs. Philadelphia Phillies, 3:05 p.m. ET

TeamOdds
Braves-115
Phillies-115


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One of two matchups that could go either way on Opening Day according to the best online sportsbooks. As well as the first of what is surely going to be many of big matchups in the extra-competitive NL East. The Braves are defending champs. They will likely go with Ian Anderson. He was great last year, but he still can be considered a rookie in 2021.
The Phillies renewed J.T. Realmuto, but he didn’t do a lot to help overcome the teams that were ahead of them in the division. It would be difficult to picture them starting anyone not named Aaron Nola.

Los Angeles Dodgers vs. Colorado Rockies, 4:10 p.m. ET

TeamOdds
Dodgers-300
Rockies+230


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Theoretically, the biggest mismatch. The Dodgers have an over/under of 101.5. Compare that to Colorado’s 64.5. The only question mark for the Dodgers is whether Clayton Kershaw starts or Walker Buehler does. In either case, they will have the advantage over the Rockies, even if the undervalued Germán Márquez takes the mound.

Arizona Diamondbacks vs. San Diego Padres, 4:10 p.m. ET

TeamOdds
Diamondbacks+180
Padres-225


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The Padres won the offseason. We will find out if that intangible success translates into Ws on the diamond. San Diego signed Fernando Tatis Jr. to a huge extension. They added Yu Darvish and Blake Snell to an already impressive roster. It is just a matter of time to see if the Padres start Darvish, Snell or Dinelson Lamet. Arizona will pick between Madison Bumgarner and Zac Gallen.

St. Louis Cardinals vs. Cincinnati Reds, 4:10 p.m. ET

TeamOdds
Cardinals-175
Reds+140


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The first time we see Nolan Arenado in a Cardinals uni during a regular season game will take place in Cincinnati. St. Louis will set its sights on another division championship against the Reds. The Reds let a Cy Young winner go. They remained during this offseason. The Cardinals should start Jack Flaherty, if health permits. The Reds will select between Luis Castillo and Sonny Gray.

Texas Rangers vs. Kansas City Royals, 4:10 p.m. ET

TeamOdds
Rangers-110
Royals-120


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The Royals have a few entertaining, young pitchers like Kris Bubic and Brady Singer. They traded for Andrew Benintendi too. Even with the young blood, they will probably start veteran Brad Keller. The Rangers traded Lance Lynn, so their starter should be Kyle Gibson.

Tampa Bay Rays vs. Miami Marlins, 4:10 p.m. ET

TeamOdds
Rays-175
Marlins+140


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They traded Blake Snell, but the defending AL pennant holders have Tyler Glasnow. The Marlins can choose to go with Sixto Sánchez. He proved to be one of the most skilled young pitchers in MLB last season.

New York Mets vs. Washington Nationals, 7:09 p.m. ET

TeamOdds
Mets-120
Nationals-110


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The first outing with Francisco Lindor in a regular-season game will be against the 2019 World Series champions. This game should make for the No. 1 pitching matchup of Opening Day. We are likely to see Jacob deGrom versus Max Scherzer.

Chicago White Sox vs. Los Angeles Angels, 10:05 p.m. ET

TeamOdds
White Sox-135
Angels+110


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The White Sox are the top bet in the futures odds boards of the best betting sites. They will start their sojourn against the hottest player right now. Southern California boy Lucas Giolito should appear on the mound for the White Sox. Mike Trout and Shohei Ohtani should be hitting in support of Dylan Bundy or Andrew Heaney.

Houston Astros vs. Oakland Athletics, 10:07 p.m. ET

TeamOdds
Astros-120
Athletics-110


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These bitter rivals will meet in the opening series of the season. Houston is likely to throw Zack Greinke. Oakland will pick between Mike Fiers, Sean Manaea, Jesús Luzardo and Chris Bassitt.

San Francisco Giants vs. Seattle Mariners, 10:10 p.m. ET

TeamOdds
Giants-115
Mariners-115


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The is the other matchup that could go either way according to the best betting sites. The Giants are lagging behind San Diego and Los Angeles, but they do have a strong team with. The Mariners are poised with new prospects, but it seems unlikely that we will see Jarred Kelenic. The most likely matchup would be Kevin Gausman against Marco Gonzales.